Production of Top 12 Biochemicals Selected by USDOE from Renewable Resources: Status and Innovation covers all important technological aspects of the production of biochemicals from renewable feedstock. All the important technological aspects of biomass conversion for example biomass pretreatment, enzymatic hydrolysis for cellulosic sugars production followed by the fermentation into chemicals and downstream recovery of the products is reviewed. Recent technological advancements in suitable microorganism development, bioprocess engineering for biomass conversion for cellulosic sugars production and various fermentation strategies and downstream recovery of these top 12 products is presented. Each bio-chemical selected by US Department of Energy i.e. ethanol, xylitol/sorbitol, furans (5-HMF, 2,5-FDCA, ), glycerol & its derivatives, hydrocarbons) isoprene, iso-butadienes and others), lactic acid, succinic acid, 3-hydroxy propionic acid, levulinic acid and biohydrogen/biogas is included in a single book chapter. In addition to the technical aspects of these 12 biochemicals, general technological challenges dealing with lignocellulose refining, perspectives and solutions are elaborated in the book. Also, life cycle analysis, techno-economic viability, and sustainability index of biofuels/biochemicals are comprehensively reviewed in the book.