Control-Theoretic Methods for Cyber-Physical Security presents novel results on security and defense methodologies applied to cyber-physical systems. This book takes a control and game theory perspective, treating autonomous platforms as dynamic systems. It introduces algorithmic frameworks designed to proactively and reactively safeguard these systems against catastrophic failures. The algorithms showcased encompass a wide spectrum of security techniques, from model-free detection mechanisms to unpredictability-based defense strategies, combining both model-based and data-driven approaches.