The PyPSA Handbook: Integrated Power System Analysis and Renewable Energy Modeling is a comprehensive guide to the landmark open-source platform for modeling modern energy systems. Starting from core concepts in energy system analysis, the book builds a clear theoretical foundation before progressing to advanced topics such as renewable integration, storage, grid expansion, system stability, and future developments. Designed for both newcomers and experienced users, it features layered examples, hands-on exercises, and real-world case studies. This book is an indispensable resource for students, researchers, and energy professionals.