The past is a moving target depending on the vagaries of technology, economics, politics and how researchers and professionals choose to build on it. The aim of The History of the Future of Chemical Information is to critically examine trajectories in chemistry, information and communication as determined by the authors in the light of current and possible future practices of the chemical information profession. Along with some additional areas primarily related to present and future directions, this collection contains most of the topics covered in the meeting symposium. Most of the original authors agreed to write chapters for this book. Much of the historical and even current material is scattered throughout the literature so the authors strived to gather this information into a discrete source. Faced with the rapid evolution of such aspects as mobile access to information, cloud computing, and public resource production, this book will be not only of interest but provide valuable insight to this rapidly evolving field, both to practitioners within the field of chemical information and chemists everywhere whose need for current and accurate information on chemistry and related fields is increasingly important.