Coagulation is a crucial and essential defense mechanism that is typically well-balanced and effective under normal circumstances. However, since Virchow's Triad was published in the mid-19th century, its elements have inspired an overwhelming amount of innovative and cutting-edge research, much of which was initiated at the bedside and later unraveled in the laboratory. These approaches have been multidisciplinary, driven by out-of-the-box thinking, keen observation, and problem-solving. The book explores the latest advancements in various coagulation disorders, examining their metabolic and biochemical root causes, both inherited and acquired. It aims to highlight the benefits of new and innovative developments, presenting a high-quality collection of thematic chapters. This work results from multidisciplinary and coordinated scientific efforts, offering the latest updates in the field. Therefore, this book provides a unique opportunity to stay updated on current and emerging diagnostic and therapeutic approaches to coagulation disorders and abnormalities. It explores overshoots and deficiencies, both inherited and acquired while embracing out-of-the-box thinking and exploring the unknown.