The integration of AI into information systems will affect the way users interface with these systems. This exploration of the interaction and collaboration between humans and AI reveals its potential and challenges, covering issues such as data privacy, credibility of results, misinformation, and search interactions. Later chapters delve into application domains such as healthcare and scientific discovery. In addition to providing new perspectives on and methods for developing AI technology and designing more humane and efficient artificial intelligence systems, the book also reveals the shortcomings of artificial intelligence technologies through case studies and puts forward corresponding countermeasures and suggestions. This book is ideal for researchers, students, and industry practitioners interested in enhancing human-centered AI systems and insights for future research.