This handbook is for informational purposes only. The information provided is not intended to diagnose, treat, cure, or prevent any disease or condition, including opioid use disorder. The Substance Abuse and Mental Health Services Administration (SAMHSA) does not approve or endorse any specific treatment. If you have a health condition or concern, contact a health care provider. Decisions about treatment of opioid use disorder are the sole responsibility of you and your treatment providers. Not all the options presented may be appropriate for your situation. Talk with your treatment providers about your situation and the role of medication in your recovery from opioid use disorder. Every effort has been made to ensure the information in this handbook, and on the decision support tool website for which it was developed, is accurate and up-to-date. However, medical information is continually changing and can become quickly outdated.