With the Smith family learning to adjust to their new surroundings in the town of Springdale, Ohio, Andrew and Carol Anne's sibling relationship is also going through the usual changes that comes with growing up. Andrew now wants to have more play-dates with his new friends from school and therefore isn't around as much to annoy his little sister and yet, Carol Anne still finds ways to get under his skin. Fortunately, Carol Anne makes friends of her own, especially with little Samantha Thompson and that helps her to realize why her big brother; Andrew's attitudes towards her are changing with the times.