This book presents state-of-the-art developments of orthopedic biomechanics across tissues in the musculoskeletal system at all size scales and with direct relevance to engineering and clinical applications. Discussing the relationship between mechanical loading, function, and biological performance, it first reviews basic structure-function relationships for most major orthopaedic tissue types followed by the most relevant structures of the body. It then addresses multiscale modeling and biologic considerations. It concludes with a look at applications of biomechanics, focusing on recent advances in theory, technology, and applied engineering approaches.