Knowledge is a living thing, sustained through dynamic reflexive processes. Whether at the level of cellular signaling pathways, Internet design, or sociocultural interactions, human understanding grows and accrues value through bi-directional transmission across networks of emitters and receptors. And the cross-fertilization of ideas from different sources is what keeps the process vigorous. This book represents a milestone in cultivating constructive exchange between experts and specialists from the physical, natural, economic and human science disciplines. From its sixteen original and highly personal essays portraying multiple facets of the knowledge creation process, emerge a common sense of purpose and a framework of new tools and methodologies for interdisciplinary dialogue.