This book presents a concise synthesis of the current knowledge and recent advances in the structure, organization, and functional role of the cytoskeleton in endothelial cells. Particular attention has been given to the different features of the regulation of vascular function mediated by the endothelium. Since cytoskeleton regulates the architecture of the cell and controls several fundamental aspects of intracellular signaling, this book serves as a comprehensive resource on these fascinating biological processes associated with vascular biology.