The obesity epidemic has generated immense interest in recent years due to the wide-ranging and significant adverse health and economic consequences that surround the problem. Much attention has been focused on behaviors that lead to obesity, in particular to over consumption of energy-dense food and to sedentary lifestyle. However, obesity is an extremely complex condition with poorly defined pathogenesis. Thanks to greatly enhanced research in the area, the discovery of pathways in the brain and peripheral organs that mediate energy homeostasis has provided a framework for understanding the biological basis of obesity. Metabolic Basis of Obesity adds an important new dimension to the growing literature on obesity by offering a comprehensive review of specifically how metabolic imbalance culminates in obesity. Developed by a team of expert authors, this important title discusses the principles of energy balance, genetics of body weight regulation, hormones and adipokines, and metabolic pathways in the brain, liver, muscle and fat, to name just several of the areas covered. The book also examines the connection between obesity and diabetes, cardiovascular disease and other complications. Current and future diagnostic and treatment strategies are also reviewed. Comprehensive and timely, Metabolic Basis of Obesity is an essential reference for understanding the burgeoning problem of obesity.

1. Principles of human energy metabolism [Jose Galgani, Eric Ravussin] 2. Intermediary metabolism of carbohydrate, protein and fat [Keith Tornheim, Neil Ruderman] 3. Adipose tissue development, structure, function [Jaswinder K. Sethi, Antonio J. Vidal-Puig] 4. Adipokines in health and disease [Rexford S. Ahima, Marcus D. Goncalves] 5. Neural control of feeding and energy homeostasis [Emilie Caron, Rexford S. Ahima] 6. Gastrointestinal hormones and obesity [Yan Wang, Efi Kokkotou] 7. Genes and human obesity [R. Arlen Price] 8. Classical hormones linked to obesity [Hyeong-Kyu Park, Rexford S. Ahima] 9. Inflammation and adipose dysfunction [Rachana Shah, Muredach P. Reilly] 10. Insulin resistance in the metabolic syndrome [Sudha B. Biddinger, Brice Emanuelli] 11. Pancreatic islet b-cell function in obesity [Tomoaki Morioka, Rohit N. Kulkarni] 12. Non-alcoholic fatty liver disease and the metabolic syndrome [Sonia Najjar] 13. Sleep, circadian rhythms and metabolism [Eleonore Maury, Kathryn M. Ramsey, Joseph Bass] 14. Obesity and cardiac dysfunction [Gary Sweeney, Sheldon E. Litwin, E. Dale Abel] 15. Atherogenic lipid metabolism in obesity [Sue-Anne Toh, Michael Levin, Daniel J. Rader] 16. Gut microbes, immunity and metabolism [Evelyn Hsu, Gary Wu] 17. Impact of obesity on female reproductive health [Moshood O. Olatinwo, Diana Harp, Winston Thompson, Hyeong-Kyu Park, Ronald Mathews] 18. Lessons from HIV lipodystrophy and drug-induced metabolic dysfunction [Steven Grinspoon] 19. Principles of obesity therapy [Rexford S. Ahima]