Who are the groups likely to be in the frontlines of either administering or receiving anti-HIV/AIDS-containing treatments for this disease and any associated comorbidities? The answer is frontline healthcare professionals, lay educators, and patients, especially in high-disease burden countries such as South Africa. While the reinvigorated national response to HIV/AIDS underscores the country's commitment to the health crisis, the socioeconomic costs are likely to have a lasting impact on its citizens. I have compiled a resource kit outlining some of the challenges faced in the treatment of patients with HIV, TB, and diabetes. In addition, the kit contains disease management and prevention tips suited for discussions with healthcare professionals, particularly in resource-poor settings.