Willow and Cami have escaped the clutches of Piggy time and time again. Just when the two think they're safe, they fall into the clutches of an eccentric pair of scientists who have constructed a geodesic jungle biome in the middle of the frosty mountains. And guess who's also been captured? Piggy herself!

To escape, Willow, Cami, and Piggy must contend with genetically modified adversaries the likes of which they've never seen. Can the unlikely trio escape? Or will this adventure be their last?