Combining Human Genetics and Causal Inference to Understand Human Disease and Development
| AUTHOR | Pingault, Jean-Baptiste; Richmond, Rebecca; Davey Smith, George et al. |
| PUBLISHER | Cold Spring Harbor Laboratory Press (01/31/2022) |
| PRODUCT TYPE | Hardcover (Hardcover) |
Description
In human genetics, causal inference methods leverage large omics data sets and phenotypic information to decipher various cause-and-effect relationships in human health and disease (e.g., smoking and lung cancer). The focus of such work is typically on modifiable variables (e.g., behavior or environmental exposure) that impact disease onset, progression, and outcome. A better understanding of these variables can lead to interventions and therapeutics that have a desirable impact on public health. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines advances in causal inference approaches in human genetics and how they are being used to enhance our understanding of human development and disease. The contributors discuss family-based study designs for causal inference, including twin designs, adoption designs, and in vitro fertilization designs, that separate inherited factors from perinatal environmental exposures. They also review various types of Mendelian randomization--a population-based approach that is growing in utility and popularity--as well as their integration with family-based designs. The use of these approaches to investigate causal mechanisms in specific scenarios (e.g., maternal smoking during pregnancy and ADHD in offspring) is also covered. This volume is therefore an essential read for geneticists, epidemiologists, and all biomedical scientists and public health professionals dedicated to using genetic information to improve human health.
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Product Format
Product Details
ISBN-13:
9781621823810
ISBN-10:
1621823814
Binding:
Hardback or Cased Book (Sewn)
Content Language:
English
More Product Details
Page Count:
254
Carton Quantity:
18
Product Dimensions:
7.00 x 0.80 x 10.10 inches
Weight:
1.65 pound(s)
Feature Codes:
Bibliography,
Index,
Dust Cover,
Illustrated
Country of Origin:
US
Subject Information
BISAC Categories
Science | Life Sciences - Genetics & Genomics
Science | Epidemiology
Science | Genetics
Dewey Decimal:
616.042
Library of Congress Control Number:
2021015998
Descriptions, Reviews, Etc.
publisher marketing
In human genetics, causal inference methods leverage large omics data sets and phenotypic information to decipher various cause-and-effect relationships in human health and disease (e.g., smoking and lung cancer). The focus of such work is typically on modifiable variables (e.g., behavior or environmental exposure) that impact disease onset, progression, and outcome. A better understanding of these variables can lead to interventions and therapeutics that have a desirable impact on public health. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines advances in causal inference approaches in human genetics and how they are being used to enhance our understanding of human development and disease. The contributors discuss family-based study designs for causal inference, including twin designs, adoption designs, and in vitro fertilization designs, that separate inherited factors from perinatal environmental exposures. They also review various types of Mendelian randomization--a population-based approach that is growing in utility and popularity--as well as their integration with family-based designs. The use of these approaches to investigate causal mechanisms in specific scenarios (e.g., maternal smoking during pregnancy and ADHD in offspring) is also covered. This volume is therefore an essential read for geneticists, epidemiologists, and all biomedical scientists and public health professionals dedicated to using genetic information to improve human health.
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List Price $135.00
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$133.65