The STS-75 Space Shuttle Program Mission Report summarizes the Payload activities as well as the Orbiter, External Tank (ET), Solid Rocket Booster (SRB), Reusable Solid Rocket Motor (RSRM), and the Space Shuttle main engine (SSME) systems performance during the seventy-fifth flight of the Space Shuttle Program, the fiftieth flight since the return-to-flight, and the nineteenth flight of the Orbiter Columbia (OV-102). In addition to the Orbiter, the flight vehicle consisted of an ET that was designated ET-76; three SSME's that were designated as serial numbers 2029, 2034, and 2017 in positions 1, 2, and 3, respectively; and two SRB's that were designated BI-078. The RSRM's, designated RSRM-53, were installed in each SRB and the individual RSRMs were designated as 36OW53A for the left SRB, and 36OW053B for the right SRB. The primary objectives of this flight were to perform the operations necessary to fulfill the requirements of the Tethered Satellite System-1 R (TSS-1R), and the United States Microgravity Payload-3 (USMP-3). The secondary objectives were to complete the operations of the Orbital Acceleration Research Experiment (OARE), and to meet the requirements of the Middeck Glovebox (MGBX) facility and the Commercial Protein Crystal Growth (CPCG) experiment. Appendix A provides the definition of acronyms and abbreviations used thorughout the report. All times during the flight are given in Greenwich mean time (GMT) and mission elapsed time (MET). Fricke, Robert W., Jr. Unspecified Center...