In the book "About Blood Circulation and Cardiovascular Annotations", by Professor J. Martins e Silva, the work is divided in 111 printed pages, which surgeon Jos Francisco Brand o published in 1761 with the purpose of supporting the study of blood circulation by his students. In fact, this good intention was resumed not to his own text but to a translation of a book by a French author (whose identity he did not disclose), in which Dr. Brand o, confessing not wanting to write a book, limited himself to adding comments and notes. Although the definition of the blood circulation model had been defined by William Harvey one hundred and thirty-three years earlier, it was found that this design would not be completely understood or accepted by contemporary authors and those of the following 150 years, which included the original translated work and Dr. Brand o himself. In the latter there were also detected, significant omissions of relevant works and conclusions dating back to antiquity. In the work now published, Brand o's text and the original that he translated are commented in order to foresee an evolution of the knowledge about the blood circulation and the cardiovascular system, from the first observations to the present. A prop sito da edi o da obra "Instruc a Breve sobre a Circula am do Sangue" pelo cirurgi o Jos Francisco Brand o, em 1761, Jo o Martins e Silva, Professor da Faculdade de Medicina de Lisboa e um dos mais conceituados investigadores da Hist ria da Medicina Portuguesa, revisita toda a hist ria da circula o sangu nea, apresentando, numa investiga o profunda e rigorosa, os marcos hist ricos que precederam e envolveram a descoberta, proporcionando um testemunho vivo e detalhado do enorme esfor o que foi necess rio para a sua total compreens o e aceita o.