Development of Compression Coated Colon Targeted 5-Fluorouracil Tablet
| AUTHOR | Patel, Natvarlal; Patel, Kanu; Patel, Natvarlal M. et al. |
| PUBLISHER | LAP Lambert Academic Publishing (08/20/2012) |
| PRODUCT TYPE | Paperback (Paperback) |
Description
The purpose of this study was to develop and evaluate a drug delivery system in vitro based on a compression coated tablet containing 5-fluorouracil (5-FU) in core and pectin Hydroxypropyl Methylcellulose (HPMC) mixture in coat layer. The main reason for selecting pectin was its biodegradation in colon by colonic flora. On other hand, high molecular weight HPMC increases mechanical strength of tablet coat around a drug core during its transportation in gastro-intestinal tract. Multiple regression analysis with two way ANOVA revealed that both factors had statistically significant influence for the response studied (P
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Product Details
ISBN-13:
9783659221941
ISBN-10:
3659221945
Binding:
Paperback or Softback (Trade Paperback (Us))
Content Language:
English
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Page Count:
112
Carton Quantity:
70
Product Dimensions:
6.00 x 0.27 x 9.00 inches
Weight:
0.39 pound(s)
Country of Origin:
US
Subject Information
BISAC Categories
Medical | Pharmacology
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publisher marketing
The purpose of this study was to develop and evaluate a drug delivery system in vitro based on a compression coated tablet containing 5-fluorouracil (5-FU) in core and pectin Hydroxypropyl Methylcellulose (HPMC) mixture in coat layer. The main reason for selecting pectin was its biodegradation in colon by colonic flora. On other hand, high molecular weight HPMC increases mechanical strength of tablet coat around a drug core during its transportation in gastro-intestinal tract. Multiple regression analysis with two way ANOVA revealed that both factors had statistically significant influence for the response studied (P
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