Traditsionno ishemicheskaya bolezn' serdtsa (IBS) rassmatrivaetsya kak bolezn' muzhchin srednego i pozhilogo vozrasta, chto chasto privodit k nedootsenke riska razvitiya etogo zabolevaniya u zhenshchin, kak samimi patsientkami, tak i vrachami. V ryade issledovaniy pokazano, chto unikal'nym zhenskim faktorom riska zabolevaniy serdechno-sosudistoy sistemy yavlyaetsya menopauza. Gipoestrogenemiya igraet rol' puskovogo faktora v razvitii kompleksa narusheniy, vkhodyashchikh v ponyatie menopauzal'nyy metabolicheskiy sindrom, chto sozdaet substrat dlya progressirovaniya IBS. Vyyavlennye v issledovanii osobennosti narusheniya lipidnogo obmena, immuno-vospalitel'nye izmeneniya u zhenshchin so stenokardiey v zavisimosti ot faz klimaksa pokazali, chto formirovanie tak nazyvaemogo menopauzal'nogo metabolicheskogo sindroma, nachinaetsya uzhe na rannem etape razvitiya klimaksa v faze perimenopauzy. Provedenie kompleksnogo obsledovaniya zhenshchin v perimenopauze pozvolit opredelit' differentsirovannyy podkhod k korrektsii metabolicheskikh i immuno-vospalitel'nykh izmeneniy, chto predotvratit progressirovanie zabolevaniya i uluchshit kachestvo zhizni zhenshchin.