Miconazole nitrate were used as antifungal agent, The main aim of this research study was to formulate transdermal patch of miconazole nitrate and it is evaluted for its surface endurance, thickness, moisture content, surface pH and in vitro release and its comparative study with marketed formulation. We finds better results in all respects of pH, surface endurance, moisture content, in vitro release pattern of drug from the transdermal patch and also compared to marketed preparation of miconazole nitrate. finally concluded that the prepared transdermal patch should be beneficial in all respects.