Meningiomas are generally benign tumors that commonly affect females, leading to symptoms primarily due to pressure on surrounding brain structures and increased intracranial pressure. The historical context of meningioma treatment includes notable figures like Felix Platter and Harvey Cushing, who contributed to our understanding and terminology of these tumors.This book emphasizes the limitations of traditional therapies and advocates for a pharmacotherapeutic approach using hydroxy urea, which has shown modest efficacy when used alone. Combing hydroxy urea with tamoxifen is proposed. This combination aims to enhance treatment effectiveness while reducing side effects, providing a promising option for patients with unresectable or recurrent meningiomas. The book underscores the need for further research to optimize treatment strategies in managing benign meningiomas.