Vopros o vzaimootnoshenii pitaniya i zdorov'ya ostaetsya odnoy iz naibolee ostrykh problem nastoyashchego vremeni. Vysokozhirovoy ratsion yavlyaetsya faktorom riska razvitiya zabolevaniy serdechno-sosudistoy, gepatobiliarnoy, zheludochno-kishechnoy sistem, prichinoy zapuska v organizme kaskada neyroendokrinnykh i immunometabolicheskiy adaptatsionnykh perestroek. Esli neyroendokrinnym mekhanizmam adaptatsii posvyashcheno mnogo rabot, to fiziologicheskim immunnym i biokhimicheskim fluktuatsiyam, proiskhodyashchim pod deystviem vysokozhirovogo ratsiona, udeleno nedostatochno vnimaniya. Vmeste s tem, immunometabolicheskaya adaptatsiya, vklyuchayushchaya perestroyki v immunnoy sisteme, okislitel'no-vosstanovitel'nykh protsessakh, lipidnom metabolizme na urovne kletochnykh membran yavlyaetsya posledney liniey zashchity, vsled za kotoroy nastupayut fiziologicheskie reaktsii. V monografii predstavleny eksperimental'nye dannye po vliyaniyu kratkosrochnoy i prolongirovannoy vysokozhirovoy diety na immunometabolicheskiy status organizma i morfo-funktsional'noe sostoyanie pecheni. Raskryvayutsya fiziologicheskie kletochno-molekulyarnye mekhanizmy adaptatsii organizma k alimentarnoy vysokozhirovoy nagruzke. Razrabotana programma optimizatsii protsessov adaptatsii.