The manual is devoted to the analysis of international experience in the formation of the organizational-administrative mechanism biotech cluster analysis of preconditions and the main approaches to the formation of biotechnology cluster in the Primorsky Territory. Relevance of the topic is determined by the main vector of development of the national economy, providing for the growth of competitiveness in the new knowledge-intensive sectors in the advanced development of high-tech industries and the transformation of innovation factors in the main source of economic growth. To achieve the objectives required the interaction of government, business, science and education based on modern, efficient development tools, among which an important role to play cluster approach. In the theoretical part of the indications we discussed the problem of modern biotechnological research trends and patterns of cluster formation as a tool of the industry. The analytical part is devoted to the analysis of prerequisites for the formation of biotechnology cluster in the Primorsky Territory. It contains a detailed description of economic and geographic potential of the region, determined by scientific research base, intellectual potential and practical experience in the field of biotechnology. Identified potential approaches and perspectives of cluster formation and constraints of its development. It shows the state's role in the formation of clusters policy.