In search combination of thermotropic LC Property and biological activity possessing property have been matched in chalconyl derivatives. Such combination of dual character has inspired for the study of novel substances which may be potentially capable and important for LC devices and for the pharmaceutically antibacterial, antimalarial, anticancer, etc. Therefore present investigation is planned with a view to understand and establish the relation between thermotropic LC properties and the molecular structure of a substance or substances through synthesis of novel chalconyl ester series of homologues. Such novel homologues may be useful for extending and continuing the research activity of groups of researchers working on LC state with different aims, objects and views at different angleThe aim of this book is to provide a brief biological profile of newly synthesized of novel chalconyl ester series of homologues. We have included the synthesis, characterization and antimicrobial screening of chalconyl ester series. This study is carried out Dr Bijendra Jain, Department of Chemistry Department, Gujarat University, Ahemdabad (Gujarat).