Typical HUS is a pathology related to an infectious colitis with Escherichia coli, often endemic, but sometimes episodic, while HUS a is a hereditary disease with a pediatric onset and a systemic and chronic symptomatology. The difficulty of the disease lay in the ARF, which led the children to dialysis rapidly, and its management in intensive care, for weights often lower than 15 kg. Diagnostic erraticity was clearly found in families with HUS a, with death occurring in the majority of cases in one or more members of the family. The lack of knowledge of this pathology due to the diversity of the clinical presentation and the therapeutic management, makes this disease serious.This manual is a review of recent literature with some real clinical cases illustrated, and is intended for: externs, medical interns, general practitioners and even specialists (pediatricians, internists, surgeons ...) and aims to make this disease known to the medical and paramedical profession. In conclusion, I would like to dedicate this book to all my colleagues, residents and doctoral students, and to my colleagues around the world.