Heterocyclic chemistry has long stood at the forefront of pharmaceutical and medicinal research, owing to its immense therapeutic potential and structural diversity. Among the wide array of heterocyclic compounds, triazoles and oxadiazoles have emerged as particularly significant due to their diverse biological activities and favorable pharmacokinetic profiles. This book is the result of a focused effort to contribute to this important domain by synthesizing and evaluating novel compounds that incorporate both 1,2,4-triazole and 1,3,4-oxadiazole moieties.The present work aims to synthesize Schiff bases containing a 1,2,4-triazole nucleus, further hybridized with an oxadiazole scaffold, and to evaluate their in-vitro antimicrobial properties. The synthesis strategies employed include the use of key intermediates such as thiocarbohydrazide, nicotinahydrazide, and appropriately substituted benzaldehydes. Careful selection of reagents and conditions allowed for efficient synthesis and subsequent characterization of the target compounds.