This pharmacology-I Lab Manual is based on PCI-Syllabus in B.Pharm Second Year. To search for new and newer agents to combat the modified as well as existing and new ill effects is a great challenge today. The availability of easy, economical, and quick methods for the evaluation of test drugs is also a key to success. It is also helpful for the discovery and development of drugs from natural, synthetic, and semi-synthetic pathways. To develop some laboratory test methods for pharmacological evaluation of crude/drugs. Ease of handling, less time consumption, and economy are also major considerations here. This lab manual is veryful for students.