Objective: The objective of the present investigation was to development of enteric coated tablet of fenoprofen calcium. Methods: The 32factorial design was used to preparation of compression?coated with a mixture of time dependent hydrophilic swellable polymer hydropropylcellulose (HPC), time released polymer Ethyl cellulose (EC) and pH responsive soluble polymer Instacoat EN Super II. The developed formulations were characterized for angle of repose, density, carr's index of powder mixture and thickness, diameter, hardness, friability, weight variation, uniformity content, in vitro disintegration, dissolution study. Results: The results showed that disintegration time and dissolution study of inner core tablet found to be in the range of 7.15 to 13.34 min and 95.92 0.011% at 30 min. The press coat tablets at optimum concentrations of hydroxy propyl cellulose (200 mg) and ethyl cellulose N-22 (200 mg) showed the % drug release 83.53 0.014% at 12 hr. % cumulative drug release of enteric coated tablet of optimized batch FT9 showed 76.08 0.045 at 12h, it indicated that drug release at sustained manner.