The subprosthetic stomatitis is a chronic inflammatory lesion of the buccal mucosa, the etiology is multifactorial always related to the use of prosthesis. Multiple are the treatments used where Ozone Therapy occupies an important space, this therapeutic modality has been analyzed from the perspective of its effectiveness where the gender analysis has not been taken into account, in these cases the disaggregation by sexes is made and an analysis is made from the biological point of view, However, gender analysis is not based on biological differences, but rather on the social differences generated by being a man or a woman in a given context and has a historical character, which is based on the fact that one of the dimensions of social inequality is the relationship between women and men, together with others such as social class, ethnicity and region of residence. The use of this approach enriches the explanatory frameworks of the health-disease process, as well as the response to certain treatments. Therefore, it is necessary to include gender in the analysis of the effectiveness of ozone therapy in the treatment of subprosthetic stomatitis.