The first part of this book is an exhaustive review of the bibliography on the history, pathogenesis, clinic, anatomopathology and new therapies for AA amyloidosis. The second part deals with the Algerian experience of the epidemiology of this rare renal pathology, which is little known to the medical public, It should be noted that systemic amyloidosis is a pathology that can affect all organs apart from the central nervous system, but the kidney is the preferred site of involvement. Our specialty has enabled us to take an interest in this pathology and its various etiologies, as well as in treatment, which is generally targeted to the causal etiology. In our Maghreb and North African country, tuberculosis is the most frequent cause of AA systemic amyloidosis, despite various programs to combat this condition, as well as rheumatic diseases, IBD and familial Mediterranean fever.This book is dedicated to medical students: externs, interns, residents and assistants in all specialties.