Welcome to this captivating journey into the heart of endometriosis, a complex disease that defies our scientific understanding. In these pages, we explore endometriosis from an innovative angle, highlighting the central role of proteases in its development and progression.By exploring the complex molecular mechanisms underlying this condition, we venture beyond conventional explanations to propose new research perspectives. Emerging theories, such as retrograde menstruation and coelomic metaplasia, are examined in detail, offering an in-depth understanding of this complex gynecological disease.We also delve into the field of magnetic resonance imaging (MRI) and isotope labeling, exploring how these groundbreaking techniques can potentially revolutionize our understanding and approach to endometriosis.Finally, we open up new research perspectives, highlighting the importance of this renewed understanding in guiding future therapeutic developments and improving the quality of life of women affected by this condition.