Import substitution is an indispensable element of the development of Belarusian industries and regions, as it is aimed at increasing export potential, expanding the range and improving the quality of products, re-equipping enterprises, and reducing the import component in the cost of finished products. In 2024, Belarus will produce import-substituting products worth about thirty billion dollars. Belarusian enterprises sold most of these products for export. And in 2025, the Ministry of Economy of Belarus expects an even higher figure - more than 31 billion dollars. The experience of the "One District - One Project" initiative, which gives a new impetus to the development of Belarusian regions and strengthens the economy not only of enterprises, but also of districts as a whole, will be used in solving this task. Today, this policy is developing quite successfully in Belarus. Import-substituting products are in demand not only in our country, but also have a good export potential. They use local raw materials and actively involve scientific developments in their production. How are these issues solved in practice? This is the subject of this paper.