Thirty years after the birth of the World Wide Web, what has been achieved by the application of information technology to the literary, historical, artistic and philosophical disciplines? Is there a new digital perspective for humanistic knowledge that can be said to be inspired by a common and shared strategy? These are some of the questions that the international conference DH.22 attempted to answer. Digital Humanities 2022, held at the Department of Humanities of the University of L'Aquila. The volume of proceedings published here represents a current reflection on the most innovative solutions of the digital transition, illustrating some research projects, already online or still in progress, identified among those most representative in the complex and varied panorama of the Digital Humanities.