This Safety Guide is a revision of IAEA Safety Standards Series No. NS-G-4.4, which it supersedes. The revised version provides specific recommendations on developing, formulating and presenting the operational limits and conditions as well as the operating procedures for research reactors, to meet the relevant requirements of IAEA Safety Standards Series No. SSR-3, Safety of Research Reactors. The recommendations in this publication are intended for use by operating organizations of research reactors, regulatory bodies and other relevant organizations involved in a research reactor project.