The book presents a collection of chapters dealing with a wide selection of topics concerning different applications of modeling. It includes modeling, simulation and optimization applications in the areas of medical care systems, genetics, business, ethics and linguistics, applying very sophisticated methods. Algorithms, 3-D modeling, virtual reality, multi objective optimization, finite element methods, multi agent model simulation, system dynamics simulation, hierarchical Petri Net model and two level formalism modeling are tools and methods employed in these papers.