A DNA computer is a collection of specially selected DNA strands, which when encoded into specific combinations are then subjected to bio-molecular manipulation in order to solve computational problems. Rather than storing information in the 1s and 0s of the binary number system, it is now stored in the form of the bases adenine (A), thymine (T), cytosine (C) and guanine (G). These bases can be arranged into short sequences of DNA that are then artificially synthesised for use as algorithmic inputs. The remarkable advantages of DNA computing, including dense data storage, massively parallel computation, and extraordinary energy efficiency, underscore its potential to revolutionize conventional computing. This innovative approach aligns with a broader trend of harnessing natural processes as computational models.DNA Logic Design: Computing with DNA not only unravels the theoretical intricacies but also navigates the practical challenges, offering a comprehensive exploration of a groundbreaking field at the intersection of biology and computer science. The book starts with the basics of DNA computing, and then describes the fundamental operations of DNA computing. Various kinds of logical designs are then translated into the DNA computing context: arithmetic circuits, combinational circuits, sequential circuits, memory devices, programmable logic devices, and nano processors. Heat and speed calculation techniques round off the book.