In the evolving landscape of global construction and design, the role of HVAC systems has transcended mere climate control. Once seen as a secondary, behind-the-scenes utility, HVAC is now at the forefront of creating intelligent, sustainable, and resilient built environments. This book, "Advanced HVAC System Design: Integrated Building Performance and Resilience," is born from the critical need to address this paradigm shift. It is a comprehensive guide that moves beyond traditional engineering principles to explore the intricate connections between heating, ventilation, and air conditioning and the overall performance, health, and resilience of a building. We delve into cutting-edge technologies, integrated design methodologies, and the crucial role of smart systems in meeting the demands of a changing climate and a more health-conscious society. Our goal is to empower a new generation of professionals to design systems that are not only efficient and reliable but are also a fundamental part of a building's success.