The complexities of modern buildings, especially high-rise structures, present unique challenges when it comes to life safety and operational efficiency. The systems that keep these environments comfortable and functional-HVAC (Heating, Ventilation, and Air Conditioning), electrical, and plumbing-are meticulously engineered to work together. However, in a crisis like a fire, the failure of even one component can have cascading and catastrophic effects. This book, authored by a leading expert in the field, delves into the critical role of these systems during a fire event. It provides a comprehensive analysis of the potential vulnerabilities, from smoke spread through ventilation ducts to the failure of fire suppression and communication systems. By understanding the "what ifs," we can better design, operate, and maintain buildings to protect lives and property. This work serves as an essential guide for engineers, architects, building managers, and first responders, offering actionable insights to enhance fire safety protocols and resilience in the face of disaster.