There are provided measures for cell clustering based configuration of flexible time division duplex communication, such as e.g. in layered heterogeneous network deployments. Such measures may exemplarily comprise measures for specifying a desired uplink-downlink configuration for time division duplex communication in a subject cell of a cellular communication system, obtaining at least one desired uplink-downlink configuration for time division duplex communication in at least one neighboring cell of the cellular communication system, wherein the at least one neighboring cell and the subject cell belong to the same cell cluster, and defining an uplink-downlink configuration for time division duplex communication in at least the subject cell of the cell cluster out of a set of predefined uplink-downlink configurations with flexible subframe patterns for flexible time division duplex communication on the basis of the specified desired uplink-downlink configuration for the subject cell and the obtained at least one desired uplink-downlink configuration for the at least one neighboring cell.