Introduction: Hemoglobinopathies are constitutional disorders resulting from abnormalities of hemoglobins. They are often severe in their major forms. The objective of our work is to report the state of hematological parameters following a prospective study carried out in patients with homozygous SS sickle cell disease in stationary phase in the Rabat - Sal - Kenitra region. Material and methods: Our cross-sectional descriptive study was carried out on 87 subjects from the Rabat - Sal - Kenitra region to determine the profile of hematological parameters of the Moroccan homozygous SS sickle cell disease. This biological study was preceded by a study on the prevalence of the different forms of hemoglobinopathies in the same region in a population at risk (case-based study). The index cases are followed up at the pediatric service at the Provincial Hospital El Idrisi of Kenitra in Morocco. A descriptive cross-sectional study was carried out during two surveys on the vaccination days of the index cases against pneumococcus.