Industry 4.0 is a European term that refers to the digital transformation in the industry, or also known as the Fourth Industrial Revolution. In the United States it is called Smart Factory, or Smart Factory. In the first part of the book, it is intended to explain carefully and in depth the new emerging technologies that come from computer engineering, electronics and telecommunications. Among others, industrial robotics, the internet of things, artificial intelligence, information systems such as Big Data, CIM, MRP and ERP, Blockchain or cybersecurity are detailed. In the second part of the book, techniques that come from mechanical engineering and industrial organization are developed. It explains about production management, quality, supply chain management and warehouse management. Finally, in the third part of the book, a series of tools from business administration are presented to give a global approach to the management of companies in the present and the future. The book gathers all the emerging technologies from the different fields of engineering and management so that the reader has a complete vision of how to adapt to the digital transformation of the industry without being left behind.