The integration of machine learning, predictive analytics, and optimization techniques revolutionizes the understanding and management of complex systems. From supply chains and energy grids to healthcare and financial markets, these systems are characterized by dynamic interactions, uncertainty, and large data amounts. Machine learning enables insights into data patterns, analytics predict future behaviors, and optimization methods guide decision-making. When combined, these tools offer solutions for enhancing system performance, resilience, and adaptability. As complexity grows, their collaboration becomes vital for creating intelligent, responsive, and sustainable systems. Machine Learning, Predictive Analytics, and Optimization in Complex Systems examines the integration of intelligent technologies into system design and management, and data analysis. It explores strategies for data-informed decisions, intelligent technology utilization, and security optimization. This book covers topics such as computer engineering, smart ecosystems, and system design, and is a useful resource for computer engineers, data analysts, academicians, researchers, and scientists.