Neurosymbolic programming combines the otherwise complementary worlds of deep learning and symbolic reasoning. It thereby enables more accurate, interpretable, and domain-aware solutions to Artificial Intelligence (AI) tasks. This monograph introduces Scallop, a general-purpose language and compiler toolchain for developing neurosymbolic applications. A Scallop program specifies a suitable decomposition of an AI task's computation into separate learning and reasoning modules. Learning modules are built using existing machine learning frameworks and range from custom neural models to foundation models for language, vision, and multi-modal data. Reasoning modules are specified in a declarative logic programming language based on Datalog which supports expressive features such as recursion, aggregation, negation, and probabilistic programming over structured relations. Scallop's compiler enables to automatically train neurosymbolic programs in a data- and compute-efficient manner using an end-to-end differentiable reasoning framework. Scallop also supports features useful for building real-world applications such as user-defined data types, soft logic operations, and foreign interfaces. This monograph demonstrates programming in Scallop for applications that span the domains of image and video processing, natural language processing, planning, and information retrieval in a variety of learning settings such as supervised learning, reinforcement learning, rule learning, contrastive learning, and in-context learning.