Non-coding RNA, Volume 214 in the Progress in Molecular Biology and Translational Science series, highlights advances in the field, with this new volume presenting interesting chapters on topics such as An introduction to non-coding RNAs, Non-coding RNAs in Eutherians and Livestocks, Artificial intelligence and machine learning heuristics for discovery of ncRNAs in humans, Non-coding RNAs in Plants, Epigenetic and experimental approaches influencing ncRNAs, Noncoding RNAs in bacteria, Dissecting ncRNA pathways and omics integration, Structural prediction of potent ncRNAs, Artificial intelligence and machine learning heuristics for discovery of ncRNAs in humans, Tools and Databases for non-coding RNAs, and Physiogenomics and genetic landscape of ncRNAs.