Thesis from the year 2024 in the subject Medicine - Other, grade: A, language: English, abstract: This Master's Thesis explores the challenges and advancements in managing patients with PBC-AIH overlap syndrome. Using data from the R-LIVER registry, the study analyzes disease progression, clinical characteristics, and the effectiveness of various treatment regimens over a 24-month period. The findings reveal that patients with overlap syndromes initially present significantly different biochemical profiles compared to those with single disease phenotypes. While treatment regimens evolve over time, the absence of standardized clinical pathways creates variability in patient management. The study underscores the need for consensus among experts and further prospective research to optimize treatment strategies for this complex patient group.