Prostate cancer remains one of the prevalent malignancies affecting men globally. It is the second leading cause of cancer-related mortality among men in the United States and many other countries.A liquid biopsy refers to a non-invasive diagnostic test that detects cancer-related biomarkers shed by tumors into the bloodstream or other bodily fluids. Early Detection and Screening Liquid biopsies have the potential to aid in the early detection of prostate cancer, particularly in high-risk populations. By analyzing PSA levels and genetic markers, liquid biopsies can provide insights into a patient's risk profile, leading to timely interventions. Monitoring Disease Progression Liquid biopsies allow for real-time monitoring of cancer progression without the need for repeated invasive procedures.